XDR typhoid infections in 5 US children linked to Pakistan outbreak

  • 5 children (aged 4-12) who traveled to or from Pakistan during late 2017 through mid-2018 have been diagnosed in the US with extensively drug-resistant (XDR) typhoid infectious
  • The outbreak in Pakistan involves a Salmonella enterica serotype Typhi strain that is resistant to most antibiotics commonly used to treat the illness
  • Between November 2016 and September 2017, 339 infections caused by the XDR Typhi strain were reported in Pakistan, with one travel-related case also reported in the United Kingdom. Enhanced surveillance efforts in Pakistan identified a total of 5,372 cases as of Dec. 30