Study spotlights high incidence of typhoid fever in sub-Saharan Africa

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  • High incidence of typhoid fever in sub-Saharan Africa necessitates typhoid conjugate vaccines (TCVs).
  • Researchers part of the Severe Typhoid in Africa study enrolled patients with fever or reported fever for 3 consecutive days within the previous 7 days. Typhoid fever was confirmed by isolating Salmonella enterica serovar Typhi from blood cultures.
  • Burkina Faso, the DRC, Ghana, and Madagascar had an adjusted typhoid incidence of over 100 cases per 100,000 person-years, with the highest in the DRC (315 cases).
  • Rural settings reported the highest incidence, however, the introduction of TCVs could substantially contribute to typhoid fever control efforts.