- A study by Broad Institute, MIT, Harvard, Tel Aviv University, and Sheba Medical Center focuses on nontyphoidal Salmonella causing long-term infections.
- Researchers analyzed bacterial samples from 256 patients with infections lasting at least 30 days, identifying mutations in barA and sirA genes.
- Mutations in these genes decrease the activity of SPI-1 genes, affecting Salmonella’s invasion of host cells.
- The study suggests the less-virulent Salmonella can sustain infections and possibly spread to other hosts.
- Different misspellings of mutated genes in different patients suggest independent evolution of bacteria to lower host immune response.
- Understanding these pathways could lead to new treatments or approaches to prevent persistent infections.
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