A new study has uncovered key details for how the Salmonella bacteria that causes typhoid fever identifies a host’s immune cells and delivers toxins that disrupt the immune system and allow the pathogen to spread
The study identifies three subunits on a typhoid toxin protein, one of which is key for delivering the toxin into host cells
The findings open the door to develop small molecules that block the high affinity trisaccharides and inhibit the toxin from binding to and entering the target cell