AUTHOR
Alexander T Yu, Nuhu Amin, Muhammad Waliur Rahman, Emily S Gurley, Kazi Mizanur Rahman, Stephen P Luby.
ABSTRACT
OBJECTIVE:
With impending rollout of new conjugate typhoid vaccines, better estimates of typhoid case-fatality ratio are needed for countries to set priorities for public health programs.
RESULTS:
We enrolled 1425 patients of all ages with blood culture–confirmed Salmonella Typhi from laboratory networks serving inpatients and outpatients in Dhaka, Bangladesh. Participants were asked about symptoms and complications including death experienced over a median 3-month period following blood culture diagnosis. Four fatal cases were identified (case-fatality ratio of 0.3% [95% confidence interval, .05%–.55%]). Applying this case-fatality ratio to global typhoid burden estimates would reduce deaths by 70%.
Click here to view the article, published in The Journal of Infectious Diseases.
