From the Blog
Investigators at the Aga Khan University in Pakistan are actively investigating a large outbreak oftyphoid fever bacteria that are resistant to ceftriaxone, an antibiotic commonly used by physicians to treat typhoid. To date, more than 250 cases of antibiotic-resistant typhoid have been identified. If this outbreak is not controlled in a timely manner, it could spread to other parts of the province and country. Read more.
Typhoid Watch
- Guatemala – An outbreak of typhoid in Petén has resulted in 60 reported cases since July 9, including two deaths
- India – Around 24 people from Boddapadu village of Krishna district with high fevers in different hospitals were diagnosed with typhoid. In Dhubri district, 176 typhoid cases have been reported due to severe flooding and a shortage of clean drinking water
- Nepal – In the wake of deadly flooding in Nepal, hospitals report a rise in typhoid cases as people resort to drinking contaminated water
- Sierra Leone – After a mudslide which killed at least 1,000 people in Freetown and left thousands more homeless, health agencies are racing to prevent outbreaks of diseases like cholera and typhoid
- Syria – Towns of the eastern Ghouta, already suffering from a shortage of medical supplies, are seeing cases of typhoid fever spreading through the countryside. Residents of the al-Yarmouk refugee camp are also being diagnosed with typhoid due to a lack of clean water
- Tonga – The Ministry of Health has recorded 25 cases of typhoid and six healthy carriers since February
- Zimbabwe – A community health group has drilled 13 chlorinated boreholes in Harare in response to the outbreak of typhoid that hit the area earlier this year
Publications
Featured
- The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26–27 October 2016, Oxford, UK – Vaccine
- Social and Economic Burden Associated With Typhoid Fever in Kathmandu and Surrounding Areas: A Qualitative Study – The Journal of Infectious Diseases
Antimicrobial Resistance
- Prevalence and trends in the antimicrobial susceptibility pattern of Salmonella enterica serovars Typhi and Paratyphi A among children in a pediatric tertiary care hospital in South India over a period of ten years: a retrospective study – European Journal of Clinical Microbiology & Infectious Diseases
Diagnostics
- How patients navigate the diagnostic ecosystem in a fragmented health system: a qualitative study from India – Global Health Action
Epidemiology
- High Rates of Enteric Fever Diagnosis and Lower Burden of Culture-Confirmed Disease in Peri-urban and Rural Nepal – The Journal of Infectious Diseases
- The global burden of disease study 2013: What does it mean for the NTDs? – PLOS Neglected Tropical Diseases
Genomics and Host Susceptibility
- Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol – Proceedings of the National Academy of Sciences of the United States of America
- In silico identification and characterization of stress and virulence associated repeats in Salmonella – Genomics
- Salmonella Typhi genomics: envisaging the future of typhoid eradication – Tropical Medicine and International Health
Microbiology
- Expression of intra- and extracellular granzymes in patients with typhoid fever – PLOS Neglected Tropical Diseases
Vaccines
- Preparedness of adolescents departing from Athens International Airport to Africa or Asia: A five-year airport-based prospective study – Travel Medicine and Infectious Disease
- Construction of an inactivated typhoid vaccine candidate expressing Escherichia coli heat-labile enterotoxin B subunit and evaluation of its immunogenicity in a murine model – Journal of Medical Microbiology
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